Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integration of Palliative Care into Primary Care: A Collaborative Effort Between the Indian Association of Palliative Care and the Indian Association of Preventive and Social Medicine.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine·2025
Same author

Adjustable tongue crib.

Journal of orthodontics·2022
Same author

Level of Knowledge, Understanding, and Impact of the COVID-19 Pandemic on Continuing Fixed Orthodontic Treatment in Adults: A Questionnaire Study.

The Journal of Indian Orthodontic Society·2021
Same author

Design and Evaluation of a Novel Mobile Phone Application to Improve Palliative Home-Care in Resource-Limited Settings.

Journal of pain and symptom management·2020
Same author

Running Palliative Care Services at the Institute of Palliative Medicine, Kozhikode, Amid COVID-19 Pandemic: A Strengths, Weaknesses, Opportunities, and Threats Analysis.

Indian journal of palliative care·2020
Same author

Primary palliative care competency framework for primary care and family physicians in India-Collaborative work by Indian Association of Palliative Care and Academy of Family Physicians of India.

Journal of family medicine and primary care·2019
Same journal

Microbial Conversations Between the Gut and Urinary Tract: Emerging Implications for Kidney and Urinary Tract Diseases.

Indian pediatrics·2026
Same journal

Prevalence and Associated Social Factors of Prediabetes in Children and Adolescents in India: A Systematic Review and Meta-Analysis.

Indian pediatrics·2026
Same journal

Comparison of Early Intrapleural Fibrinolytic Therapy, Versus Administration After Failure of Intercostal Drainage in Children with Empyema Thoracis: A Systematic Review.

Indian pediatrics·2026
Same journal

Can Nebulized Epinephrine Prevent Extubation Failure in Neonates?

Indian pediatrics·2026
Same journal

Pragmatic Respiratory Stabilization During Neonatal Intubation-What Does this Trial Add for Indian NICUs?

Indian pediatrics·2026
Same journal

Universal Early-Life Screening in India: Time for a National Integrated Strategy.

Indian pediatrics·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

Thiamine responsive megaloblastic anemia.

Lulu Mathews1, K Narayanadas, G Sunil

  • 1Institute of Maternal and Child Health, Medical College, Calicut, India. lulumathews@gmail.com

Indian Pediatrics
|February 27, 2009
PubMed
Summary
This summary is machine-generated.

Thiamine responsive megaloblastic anemia syndrome (Rogers syndrome) in a child improved with thiamine treatment. This rare condition also presented with diabetes mellitus, retinitis pigmentosa, and novel olfactory abnormalities.

More Related Videos

Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function
08:03

Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function

Published on: June 21, 2017

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin
08:07

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin

Published on: March 24, 2023

Related Experiment Videos

Last Updated: Jun 25, 2026

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function
08:03

Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N6-threonylcarbamoyladenosine TcdA Function

Published on: June 21, 2017

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin
08:07

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin

Published on: March 24, 2023

Area of Science:

  • Genetics and rare diseases
  • Metabolic disorders
  • Pediatric medicine

Background:

  • Thiamine responsive megaloblastic anemia syndrome (Rogers syndrome) is a rare genetic disorder.
  • It is characterized by megaloblastic anemia, diabetes mellitus, and sensorineural deafness.
  • This case expands the known clinical phenotype of Rogers syndrome.

Observation:

  • A female child presented with anemia and diabetes mellitus.
  • She also exhibited retinitis pigmentosa.
  • Unreported olfactory abnormalities, similar to those in Wolfram syndrome, were noted.

Findings:

  • Daily oral thiamine administration led to significant improvement in anemia.
  • Blood glucose levels were effectively controlled with thiamine supplementation.
  • The patient's clinical presentation suggests an overlap or a broader spectrum of thiamine-responsive disorders.

Implications:

  • This case highlights the critical role of thiamine in managing Rogers syndrome.
  • It suggests potential genotype-phenotype correlations and the need for comprehensive diagnostic evaluation in similar cases.
  • Further research is warranted to understand the underlying mechanisms and expand the diagnostic criteria for thiamine-responsive conditions.