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Related Experiment Video

Updated: Jun 25, 2026

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

Breastfeeding and AIDS in the developing world.

Louise Kuhn¹, Cordula Reitz, Elaine J Abrams

¹Gertrude H. Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA.

Current Opinion in Pediatrics

|February 27, 2009

Summary

Exclusive breastfeeding significantly reduces HIV transmission risk. Antiretroviral therapy for mothers or infants also lowers postnatal HIV transmission, preventing infant deaths.

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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Area of Science:

Public Health
Infectious Disease Epidemiology
Pediatrics

Background:

Hundreds of thousands of infants in developing countries acquire HIV during breastfeeding.
Replacement feeding is often not feasible or safe in these regions.
Understanding transmission risks is crucial for infant survival.

Purpose of the Study:

To review current data on feeding strategies and antiretroviral therapy (ART) for preventing postnatal HIV transmission.
To assess the safety and efficacy of different infant feeding methods.
To evaluate the impact of ART on mother-to-child HIV transmission during breastfeeding.

Main Methods:

Review of recently completed studies on infant feeding practices.
Analysis of data on antiretroviral prophylaxis for mothers and infants.
Evaluation of HIV transmission rates and infant mortality in various feeding scenarios.

Main Results:

Exclusive breastfeeding is associated with a significant decrease in HIV transmission risk.
Formula feeding or early weaning does not improve HIV-free survival due to increased uninfected infant mortality.
Antiretroviral treatment for mothers or infants reduces postnatal HIV transmission.
Daily nevirapine for breastfeeding infants shows protection during treatment.

Conclusions:

Promoting exclusive breastfeeding is vital for preventing HIV transmission.
Ensuring antiretroviral treatment for mothers with advanced HIV disease is critical.
These strategies are likely to prevent significant maternal and infant mortality.