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Fever

Avind Rampersad1, Deepa Mukundan

  • 1Department of Pediatrics, University of Toledo College of Medicine, Toledo, Ohio 43608, USA.

Current Opinion in Pediatrics
|February 27, 2009
PubMed

Insights

Accurate prediction of serious illness in febrile children requires better diagnostic markers. Future research will focus on applying host immune response understanding to fever diagnosis and management.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • Fever is a common symptom in children, necessitating accurate diagnosis and management.
  • Understanding the host's immune response is crucial for identifying the causes of fever.
  • Current diagnostic predictors for serious illness in febrile children are still under investigation.

Purpose of the Study:

  • To review current advances in the field of fever in children.
  • To explore clinical and diagnostic predictors for early diagnosis of serious disease.
  • To discuss the role of host susceptibility and immune response in fever pathogenesis.

Main Methods:

  • Comprehensive literature review of publications from the past 18 months.
  • Analysis of clinical and diagnostic predictors for serious disease in children with fever.
  • Review of host susceptibility and immune response in understanding fever pathogenesis.

Main Results:

  • Predictors for serious disease in febrile children are still being explored for targeted therapy.
  • Significant strides are being made in understanding host susceptibility and immune response in fever.
  • Efficacy of antipyretics and fever as a screening tool were also discussed.

Conclusions:

  • Improved markers are needed to predict serious bacterial infections in febrile children.
  • Clinical application of host immune response is the future direction for fever diagnosis and management.
Abstract

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