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Updated: Jun 25, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
Published on: February 22, 2020
Comorbidity in patients after stroke: impact on functional outcome
Altinay Goksel Karatepe1, Rezzan Gunaydin, Taciser Kaya
1Izmir Training and Research Hospital, Department of Physical Medicine and Rehabilitation, Izmir, Turkey. altinaygoksel@yahoo.com
Insights
Comorbid diseases are common after stroke, negatively impacting functional recovery. While their precise effect on outcomes requires further study, evaluating these conditions is crucial for stroke research.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Clinical Research
Background:
- Comorbid diseases are prevalent in post-stroke patients.
- Understanding their influence on recovery is essential for effective patient management.
Purpose of the Study:
- To determine the incidence of comorbid diseases in stroke survivors.
- To assess the impact of these comorbidities on functional outcomes.
Main Methods:
- Prospective study involving 140 post-stroke patients.
- Comorbidities assessed using the Liu comorbidity index.
- Functional Independence Measure (FIM) used to evaluate functional independence.
Main Results:
- Hypertension was the most frequent comorbidity.
- Higher baseline comorbidity index correlated with lower FIM scores and functional gain.
- Comorbidities accounted for 3.1% of the variance in follow-up functional outcomes.
Conclusions:
- Comorbidities are common and negatively associated with functional outcomes post-stroke.
- The exact impact of comorbidities on functional outcome requires further investigation.
- Integrating comorbidity assessment into stroke outcome research is recommended.
Objective:
To evaluate the incidence of comorbid diseases and their impact on functional outcome in patients after stroke.
Design:
A prospective study.
Subjects:
A total of 140 patients after stroke.
Methods:
Comorbidities were assessed with the Liu comorbidity index. Functional independence was evaluated using the Functional Independence Measure (FIM). The relationship between comorbidities and functional outcomes were investigated. The impact of comorbidities on functional outcome was examined with multiple stepwise regression analysis.
Results:
Ninety-four (67%) of 140 patients completed the study. The most frequent comorbid condition was hypertension at the initial visit. The weighted comorbidity index at baseline was negatively correlated with the follow-up FIM score and functional gain. Multiple regression analysis revealed that follow-up FIM score could be best explained by FIM at admission and the contribution of the weighted comorbidity index to functional outcome was 3.1%.
Conclusion:
Comorbid diseases are common among patients after stroke. They were shown to have a negative correlation with functional outcome; however, their impact on functional outcome was not clear. The proper evaluation of comorbid conditions should be included in stroke outcome research.
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