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Rebecca M Lucente-Schultz1, Valerie C Moore, Ashley D Leonard

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Area of Science:

  • Nanomaterials Science
  • Biochemistry
  • Materials Chemistry

Background:

  • Single-walled carbon nanotubes (SWCNTs) are explored for advanced applications.
  • Antioxidants combat oxidative stress, crucial in various biological and material contexts.
  • Butylated hydroxytoluene (BHT) is a well-known phenolic antioxidant.

Purpose of the Study:

  • To functionalize SWCNTs and ultrashort SWCNTs (US-SWCNTs) with BHT derivatives.
  • To evaluate the antioxidant capacity and cytotoxicity of these modified nanomaterials.
  • To understand the relationship between functionalization methods and antioxidant efficacy.

Main Methods:

  • Functionalization of SWCNTs and US-SWCNTs with BHT derivatives using covalent and noncovalent strategies.
  • Oxygen Radical Absorbance Capacity (ORAC) assay to measure radical scavenging ability.
  • Cytotoxicity assays to assess the effect on cell viability.

Main Results:

  • BHT-functionalized SWCNTs demonstrated significantly higher oxygen radical scavenging ability compared to dendritic fullerene (DF-1).
  • Antioxidant activity increased proportionally with BHT loading when functionalizing existing pendant sites on US-SWCNTs.
  • Covalent functionalization of BHT directly to SWCNT sidewalls showed an inverse relationship between BHT loading and antioxidant activity, suggesting the nanotube itself is a potent scavenger.
  • Both nonfunctionalized and BHT-functionalized SWCNTs exhibited minimal cytotoxicity.

Conclusions:

  • SWCNTs functionalized with BHT derivatives possess superior antioxidant properties.
  • The method of functionalization critically influences the overall antioxidant performance.
  • SWCNTs, both functionalized and unfunctionalized, are biocompatible and show promise for antioxidant material and therapeutic applications.