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Strain differences in delay discounting using inbred rats.

C J Wilhelm1, S H Mitchell

  • 1Departments of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA. wilhelmc@ohsu.edu

Genes, Brain, and Behavior
|February 27, 2009
PubMed
Summary
This summary is machine-generated.

Genetic factors influence delay discounting, a behavior linked to neuropsychiatric disorders. This study found significant differences in how rat strains value delayed rewards, suggesting a heritable component to this trait.

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Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Psychopharmacology

Background:

  • Heightened aversion to delayed rewards is linked to substance abuse and neuropsychiatric disorders.
  • Many neuropsychiatric disorders have a heritable component, suggesting a potential genetic basis for delay aversion.

Purpose of the Study:

  • To investigate the heritability of delay discounting by examining differences in six inbred rat strains.
  • To quantify strain-specific sensitivity to delayed rewards.

Main Methods:

  • Utilized the adjusting amount procedure to measure the subjective value of delayed rewards in six rat strains.
  • Fitted a hyperbolic discount equation to assess delay discounting sensitivity (k).
  • Measured sucrose solution preference and locomotor activity.

Main Results:

  • Significant strain differences in delay discounting were observed, indicating varying sensitivity to reward delays.
  • The subjective value of rewards decreased with increased delay across all strains.
  • Sucrose consumption correlated with delay sensitivity, but locomotor activity did not.

Conclusions:

  • There are significant genetic influences on delay discounting behavior in rats.
  • These findings support a heritable component to delay aversion, relevant to understanding neuropsychiatric disorders.
  • Further research is needed to differentiate genetic from maternal effects.