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Published on: January 26, 2019
CD24 expression has a prognostic impact in breast carcinoma
Pauline Athanassiadou1, Dimitra Grapsa, Maria Gonidi
11st Pathology Department-Cytology Unit, Medical School, Athen's University, Athens, Greece. dimgrap@yahoo.gr
Pathology, Research and Practice
|February 27, 2009
Summary
BAG-1 and CD24 expression in invasive breast cancer indicate a poorer prognosis. Both markers correlate with advanced stage, higher grade, and lymph node involvement, negatively impacting survival.
Area of Science:
- Oncology
- Pathology
- Biomarker Research
Background:
- Prognostic markers are crucial for tailoring breast cancer treatment.
- BAG-1 and CD24 are potential biomarkers in various cancers.
- Their role in invasive breast carcinoma prognosis requires further elucidation.
Purpose of the Study:
- To investigate the prognostic significance of BAG-1 and CD24 expression in invasive breast carcinomas.
- To correlate marker expression with established prognostic parameters and patient survival.
Main Methods:
- Immunocytochemical analysis of BAG-1 and CD24 expression in 70 invasive breast carcinoma cases.
- Correlation of marker expression with tumor stage, grade, lymph node status, tumor size, and 5-year survival.
- Univariate and multivariate analyses were performed.
Main Results:
- Positive staining for BAG-1 and CD24 correlated significantly with adverse prognostic factors: increased stage, higher tumor grade, positive lymph nodes, and larger tumor size.
- Both markers demonstrated a significant negative impact on patient survival.
- Multivariate analysis confirmed an independent prognostic value for overall CD24 staining.
Conclusions:
- BAG-1 (cytoplasmic and nuclear) and CD24 (overall and cytoplasmic) expression are associated with adverse prognostic parameters in invasive breast cancer.
- CD24 expression, in particular, holds independent prognostic value.
- These findings suggest BAG-1 and CD24 as potential prognostic indicators in invasive breast carcinoma.
