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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors
Cindy Gomez1, Longchuan Bai, Jian Zhang
1Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Bioorganic & Medicinal Chemistry Letters
|February 27, 2009
Abstract:
The STAT3 oncogene is a promising molecular target for the design of a new class of anticancer drugs. In this letter, we describe the design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as novel STAT3 inhibitors. Compound 3 binds to STAT3 with a K(i) value of 190nM and is a promising lead compound for further design and optimization.
