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Nutritional and inflammatory status of hemodialysis patients in relation to their body mass index

Ilia Beberashvili1, Inna Sinuani, Ada Azar

  • 1Division of Nephrology, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel. iliab@asaf.health.gov.il

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
|February 27, 2009
PubMed

Insights

Obese hemodialysis patients show better nutritional status than normal or overweight patients, with no difference in inflammation severity. Higher body mass index (BMI) correlates with improved nutritional markers in hemodialysis (HD) patients.

Area of Science:

  • Nephrology
  • Clinical Nutrition
  • Biochemistry

Background:

  • Obesity is prevalent in hemodialysis (HD) patients.
  • The nutritional and inflammatory status of obese HD patients remains unclear.
  • Understanding these factors is crucial for managing HD patient health.

Purpose of the Study:

  • To investigate the nutritional and inflammatory status of obese hemodialysis (HD) patients.
  • To compare these states with overweight and normal body mass index (BMI) HD patients.

Main Methods:

  • A single-center, cross-sectional study involving 96 stable HD patients.
  • Patients were categorized into normal, overweight, and obese BMI groups.
  • Measurements included anthropometry, body composition, nutritional markers, inflammatory cytokines, leptin, and soluble leptin receptor (sOB-R).

Main Results:

  • Higher BMI groups exhibited elevated serum creatinine, albumin, and transferrin.
  • Obese patients had greater lean body mass, fat mass, higher phase angle (PA), and lower extracellular mass-to-body-cell-mass ratio (ECM/BCM).
  • Inflammatory cytokine levels were similar across BMI groups, but leptin increased and sOB-R tended to decrease with higher BMI.

Conclusions:

  • Hemodialysis patients with elevated BMI demonstrate superior nutritional status compared to normal or overweight counterparts.
  • Body mass index (BMI) is not associated with the severity of inflammation in hemodialysis patients.
  • Phase angle (PA) and ECM/BCM correlate with leptin concentration, suggesting a link between body composition and hormonal markers.
Abstract

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