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Updated: Jun 25, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Food intake, dietary patterns, and actinic keratoses of the skin: a longitudinal study
Maria Celia B Hughes1, Gail M Williams, Anny Fourtanier
1Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Background:
Actinic keratoses (AKs) are premalignant actinic tumors of the skin. Evaluation of the role of diet in their development is lacking.
Objective:
The objective was to determine whether intake of certain food groups or dietary patterns retard the occurrence of AKs over a 4.5-y period.
Design:
In a community-based study of skin cancer in Queensland, Australia, food intake of 1119 adults was assessed in 1992, 1994, and 1996 by using a validated food-frequency questionnaire. Dermatologists counted prevalent AKs during full-body skin examinations in 1992 and 1996. The relative ratio (RR) of AK counts in 1996 relative to 1992 was compared across increasing intakes of 26 food groups, and for 3 dietary patterns identified by principal components analysis, with the use of generalized linear models with negative binomial distribution, allowing for repeated measures. All analyses were adjusted for confounding factors, including skin color and sun exposure indexes.
Results:
AK acquisition decreased by 28% (RR: 0.72; 95% CI: 0.55, 0.95) among the highest consumers of oily fish (average of one serving every 5 d) compared with those with minimal intake. Similarly, the rate of acquisition of AKs was reduced by 27% (RR: 0.73; 95% CI: 0.54, 0.99) in those with the highest consumption of wine (average of half a glass a day in this study population). There was no consistent association of dietary pattern with AK acquisition.
Conclusion:
Moderate intake of oily fish and of wine may decrease the acquisition of AKs and thus complement sun protection measures in the control of actinic skin tumors.
Insights
Dietary intake of oily fish and wine may reduce the development of actinic keratoses (AKs), which are premalignant skin tumors. This finding suggests that certain foods can complement sun protection strategies.
Area of Science:
- Dermatology and Nutritional Science
- Skin Cancer Research
- Preventive Medicine
Background:
- Actinic keratoses (AKs) are common premalignant skin lesions.
- The influence of diet on AK development is not well understood.
- Research is needed to identify dietary factors that may prevent AKs.
Purpose of the Study:
- To investigate if specific food groups or dietary patterns reduce the occurrence of AKs over time.
- To analyze the relationship between dietary intake and the progression of actinic keratoses.
Main Methods:
- A community-based study in Queensland, Australia, involving 1119 adults.
- Dietary intake assessed via validated food-frequency questionnaires in 1992, 1994, and 1996.
- Actinic keratoses counted during full-body skin examinations in 1992 and 1996; statistical models adjusted for confounding factors.
Main Results:
- Highest consumers of oily fish showed a 28% decrease in AK acquisition.
- Highest consumers of wine showed a 27% decrease in AK acquisition.
- No significant association found between overall dietary patterns and AK acquisition.
Conclusions:
- Moderate consumption of oily fish and wine may help reduce the development of actinic keratoses.
- Dietary interventions, particularly oily fish and wine intake, could complement sun protection measures.
- Further research into diet's role in managing actinic skin tumors is warranted.
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