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Updated: Jun 25, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
[The action of TSG101 on HIV-1 budding and related inhibitors]
1Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
Abstract:
tsg101 gene is a newly found tumor suppressor gene whose product TSG101 has many important biological functions. Recent research of TSG101 has revealed that TSG101 aids HIV-1 budding from infected cells by attaching to Gag. HIV-1 budding is arrested in the cells with mutant TSG101 or without TSG101. So TSG101 would be a useful target for anti-HIV drug design. Now there is already some research on anti-HIV agents based on TSG101 structure. In this article the structure and function of TSG101 as well as the related inhibitors were reviewed.
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