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Updated: Jun 25, 2026

Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
Published on: December 27, 2017
Idiopathic thrombocytopenic purpura
Geetha Palaniappan1, William Jennings
1Division of Hematology and Oncology, University of Missouri-Kansas City School of Medicine, USA. palaniappang@umkc.edu
Abstract:
Immune Thrombocytopenic Purpura (ITP) is an immune mediated disorder characterized by low platelet counts from peripheral destruction. While in children the disease is self-limiting, in adults it runs an insidious and chronic course. The goal of treatment should be the maintenance of a platelet count sufficient to prevent bleeding. Most of the earlier treatment regimens such as corticosteroids, intravenous immunoglobulin and splenectomy were directed towards reducing peripheral destruction. However, newer agents to stimulate thrombopoiesis are under investigation and have demonstrated early encouraging results.
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