Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-exposure to cannabinoids and nicotine increases senescence in prenatal human lung development.

Pediatric research·2026
Same author

Autophagy as a Redox Rheostat Linking Cigarette Smoke, Electronic Cigarettes, and Nicotine Exposure to Lung Development, Disease, and Interorgan Communication.

Comprehensive Physiology·2026
Same author

Perinatal Nicotine Exposure-Induced Cardiac Phenotype Is Mediated by miR-1-MIAT Interaction and Is Transmitted Transgenerationally.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells.

Frontiers in pharmacology·2026
Same author

The protective effect of maternal electroacupuncture on prenatal nicotine exposure-induced intrauterine growth restriction in rats by improving placental angiogenesis.

Chinese medicine·2026
Same author

A Rapid Fluorescence Method for In Vivo Quantitation of Lung Deposition of a Nebulized Drug: Multiple Uses for Advancing Aerosolized Drug Development and Specific Insight Regarding Aerosolized Vitamin A for Preventing Bronchopulmonary Dysplasia.

Methods and protocols·2025

Related Experiment Video

Updated: Jun 25, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Leptin stimulates Xenopus lung development: evolution in a dish.

J S Torday1, Kaori Ihida-Stansbury, Virender K Rehan

  • 1Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. jtorday@labiomed.org

Evolution & Development
|February 28, 2009
PubMed
Summary

The metabolic hormone leptin stimulates lung development and surfactant synthesis, linking metabolism to respiration and locomotion. This study reveals leptin

More Related Videos

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
07:32

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Live-cell Imaging and Quantitative Analysis of Embryonic Epithelial Cells in Xenopus laevis
06:51

Live-cell Imaging and Quantitative Analysis of Embryonic Epithelial Cells in Xenopus laevis

Published on: May 23, 2010

Related Experiment Videos

Last Updated: Jun 25, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
07:32

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Live-cell Imaging and Quantitative Analysis of Embryonic Epithelial Cells in Xenopus laevis
06:51

Live-cell Imaging and Quantitative Analysis of Embryonic Epithelial Cells in Xenopus laevis

Published on: May 23, 2010

Area of Science:

  • Evolutionary biology
  • Developmental biology
  • Endocrinology

Background:

  • Multicellularity requires metabolic cooperation.
  • Soluble growth factors mediate cell-cell interactions.
  • Leptin is an environmentally sensitive, pleiotropic hormone involved in metabolic regulation.

Purpose of the Study:

  • To demonstrate leptin's role in integrating metabolic regulation with lung development.
  • To investigate the effects of leptin on Xenopus laevis tadpole lung development.
  • To link leptin's effects to the evolution of vertebrate respiration and locomotion.

Main Methods:

  • Empirical demonstration of leptin's mechanism.
  • Analysis of lung development in Xenopus laevis tadpoles.
  • Comparative analysis across vertebrate lung evolution.

Main Results:

  • Leptin stimulates lung development, thinning the gas exchange surface.
  • Leptin increases lung surfactant synthesis.
  • These processes mirror vertebrate lung evolution from fish to humans.

Conclusions:

  • Leptin provides a mechanistic link between metabolic regulation and physiological structures/functions.
  • Leptin drives the evolution of Gene Regulatory Networks from cells to systems.
  • This model offers insights into the evolution of complex vertebrate physiology.