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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Snail1 is over-expressed in prostate cancer
Sara Heebøll1, Michael Borre, Peter David Ottosen
1Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Brenstrupgaardsvej 100, Aarhus N, Denmark. saraheeboll@dadlnet.dk
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|February 28, 2009
Summary
Transcription factor Snail1 is upregulated in prostate cancer (PC), even in early stages. This finding suggests Snail1 may play a role in PC development and could be a potential biomarker.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Transcription factor Snail1 is crucial for cell migration and survival.
- Elevated Snail1 expression is observed in various cancer types.
- The Snail1 gene is reportedly amplified in prostate cancer (PC).
Purpose of the Study:
- To investigate the expression levels of Snail1 in prostate cancer tissues.
- To determine the correlation between Snail1 expression and clinicopathological features of PC.
- To assess the role of Snail1 in the early stages of PC development.
Main Methods:
- Immunohistochemical staining of Snail1 was performed on a tissue microarray.
- The study included 327 PC specimens, 30 benign prostatic hyperplasia (BPH) specimens, 30 benign PC tissues, and 15 high-grade prostate intraepithelial neoplasia (high-grade PIN) specimens.
- Clinicopathological and follow-up data were analyzed in conjunction with Snail1 expression levels.
Main Results:
- High Snail1 expression was detected in approximately 50% of PC tissues, compared to minimal expression in BPH, benign tissues, and high-grade PIN.
- Snail1 immunostaining significantly correlated with Gleason score (p<0.05).
- Snail1 expression was significantly increased in PC, correlating positively with dedifferentiation but not with cancer progression or prognosis.
Conclusions:
- Snail1 expression is upregulated from the early stages of prostate cancer.
- Snail1 upregulation is associated with dedifferentiation in PC.
- These findings highlight Snail1 as a potential marker for early-stage PC.
