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Related Experiment Videos

Hyperbaric oxygen therapy in plastic surgery: a review article.

E P Kindwall1, L J Gottlieb, D L Larson

  • 1Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, Milwaukee.

Plastic and Reconstructive Surgery
|November 1, 1991
PubMed
Summary

Hyperbaric oxygen therapy (HBOT) enhances wound healing by boosting immune cell function and tissue repair. It is particularly effective for problem wounds like diabetic extremities and burns, improving outcomes and reducing recovery time.

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Area of Science:

  • Medicine
  • Surgery
  • Wound Healing

Background:

  • Hyperbaric oxygen (HBO) therapy has demonstrated significant effects beneficial to surgical outcomes.
  • Key effects include enhanced leukocyte microbial killing, fibroblast replication, and collagen formation.
  • HBO also promotes neovascularization in ischemic tissues.

Purpose of the Study:

  • To review the surgical applications and benefits of hyperbaric oxygen therapy.
  • To highlight HBO's role in managing specific challenging wound conditions.
  • To discuss the mechanisms and outcomes of HBO in various surgical contexts.

Main Methods:

  • Review of existing literature on hyperbaric oxygen therapy in surgical and wound healing contexts.
  • Analysis of HBO's physiological effects on cellular and tissue levels.

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  • Compilation of reported outcomes for conditions like radionecrosis, osteomyelitis, necrotizing fasciitis, crush injuries, compartment syndrome, burns, and diabetic extremities.

    • Main Results:

    • HBO stimulates leukocyte activity, fibroblast replication, collagen formation, and neovascularization, particularly in ischemic tissues.
    • Preoperative HBO aids neovascularization in radionecrotic tissue.
    • Adjunctive HBO shows promise in treating refractory osteomyelitis and necrotizing fasciitis.
    • HBO benefits crush injuries and compartment syndrome by preserving ATP and limiting edema.
    • In burn injuries, HBO leads to shorter hospital stays, fewer surgeries, and reduced fluid replacement.
    • HBO improves the success rate and speed of skin grafts and flaps.
    • Mechanisms may extend to ischemic problem wounds, including infected diabetic extremities.

    Conclusions:

    • Hyperbaric oxygen therapy offers significant benefits in various surgical scenarios, especially for complex and problem wounds.
    • While not accelerating normal wound healing, HBO can significantly improve outcomes for compromised tissues and specific conditions.
    • Understanding HBO's mechanisms and contraindications is crucial for optimizing its therapeutic application in surgery.