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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
[Correlation between cardiovascular risk factors and the severity of coronary artery lesions in female patients]
Wei Hu1, Zhi-gang Guo, Jun Chen
1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. hwhd611@163.com
Insights
High LDL-C is the primary risk factor for coronary artery disease (CAD) in women. Other factors like diabetes and uric acid also significantly impact CAD severity.
Area of Science:
- Cardiovascular Medicine
- Clinical Research
- Epidemiology
Background:
- Coronary artery disease (CAD) poses a significant health burden in women.
- Understanding traditional and emerging cardiovascular risk factors is crucial for managing CAD severity.
Purpose of the Study:
- To examine the link between cardiovascular risk factors and the extent of coronary artery lesions in female CAD patients.
- To identify the most significant independent risk factors for CAD severity in this population.
Main Methods:
- Coronary angiography was performed on 235 female patients (156 with CAD, 76 without).
- Univariate and multivariate analyses were used to assess cardiovascular risk factors and lesion severity.
Main Results:
- Increased CAD severity correlated with hypertension, type 2 diabetes, dyslipidemia (high triglycerides, total cholesterol, LDL-C; low HDL-C), high uric acid, and high fibrinogen.
- Multivariate analysis identified high LDL-C as the strongest independent predictor, followed by diabetes, triglycerides, uric acid, low HDL-C, hypertension, and age.
Conclusions:
- Female CAD patients face numerous risk factors, with high LDL-C being paramount.
- Emerging factors like elevated uric acid warrant clinical attention in managing female CAD.
Objective:
To investigate the association of the traditional and newly emerged cardiovascular risk factors with the severity of coronary artery lesion in female patients with coronary artery disease (CAD).
Methods:
This study involved 235 female in-patients undergoing coronary angiography, including 156 with confirmed coronary artery disease (CAD) and 76 non-CAD patients. Univariate and multivariate analysis of the cardiovascular risk factors and the severity of coronary artery lesion were carried out in these patients.
Results:
Univariate analysis showed that in the CAD patients of different severities, increased number of compromised arteries and total Gensini scores for the lesions were associated with increased incidences of the such risk factors including hypertension, type 2 diabetes, high triglycerides, high total cholesterol, low high-density lipoprotein cholesterol (HDL-C) level, high low density lipoprotein cholesterol (LDL-C) level, high uric acid level and high fibrinogen level. Multivariate regression analysis showed that high LDL-C level was the most significant independent risk factor for CAD, followed by diabetes, triglycerides, high uric acid, low HDL-C, high blood pressure and age.
Conclusions:
Female CAD patients are exposed to multiple risk factors, among which high LDL-C level is the most significant independent risk factor, but the other risk factors, especially the newly emerged factor uric acid, should be given due attention in the patients.
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