Related Experiment Videos
Venlafaxine in depressed outpatients
Psychopharmacology Bulletin
|January 1, 1991
Summary
This study found that venlafaxine significantly improved mood symptoms in depressed outpatients compared to placebo. This novel antidepressant was well-tolerated, with nausea as the most frequent side effect.
Area of Science:
- Pharmacology
- Clinical Psychology
- Psychiatry
Background:
- Venlafaxine is a novel compound with potential antidepressant properties.
- Depression is a prevalent mood disorder requiring effective treatments.
Purpose of the Study:
- To assess the efficacy and safety of venlafaxine in treating major depression.
- To evaluate different dosages of venlafaxine against a placebo control.
Main Methods:
- Phase II, double-blind, placebo-controlled clinical trial.
- 93 depressed outpatients received venlafaxine (25, 75, or 125 mg t.i.d.) or placebo.
- Mood symptoms were assessed to compare treatment groups.
Main Results:
- Venlafaxine treatment resulted in significantly greater improvement in mood symptoms versus placebo.
- Venlafaxine was well-tolerated by the study participants.
- Nausea was the most commonly reported side effect.
Conclusions:
- Venlafaxine demonstrates antidepressant activity in outpatients with depression.
- Early evidence suggests potential antidepressant effects within two weeks of treatment initiation.
- Venlafaxine represents a potentially effective and safe treatment option for depression.