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Published on: October 5, 2015
Leptin response in patients with tuberculous pleuritis.
C Prabha1, P Supriya, Sulochana D Das
1Department of Immunology, Tuberculosis Research Centre (ICMR), Chennai, India.
The Indian Journal of Medical Research
|February 28, 2009
Summary
Leptin levels in pleural effusions were lower in tuberculous pleuritis patients compared to non-tuberculous cases. Decreased leptin correlated with reduced body mass index (BMI), not disease status, in this tuberculosis model.
Area of Science:
- Immunology
- Tuberculosis Research
- Metabolic Markers
Background:
- Tuberculous pleuritis serves as a model for studying tuberculosis (TB) immune responses.
- A Th1-dominant response is characteristic of TB infection.
- Leptin, a known Th1 response enhancer, was investigated for its role.
Purpose of the Study:
- To investigate leptin levels in pleural effusions of patients with tuberculous pleuritis (TP) versus non-tuberculous pleuritis (NTP).
- To explore the relationship between leptin, body mass index (BMI), and disease status in TP.
Main Methods:
- Leptin and cytokine levels were measured using ELISA in serum and pleural fluid from TP and NTP patients (N=20 each).
- Multivariate regression analysis identified determinants of leptin, including BMI, gender, source (serum/pleural fluid), age, and disease status.
Main Results:
- Pleural fluid leptin levels were higher than serum levels in both groups.
- TP patients exhibited significantly lower pleural fluid leptin levels compared to NTP patients.
- Leptin levels were dependent on BMI but not other tested parameters; males were better predictors of leptin source.
Conclusions:
- Decreased leptin levels in tuberculous pleuritis are associated with reduced BMI.
- Leptin levels did not show a direct correlation with the disease status in tuberculous pleuritis.
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