Bilateral uneven cataracts in children: amblyopia management by sequential intraocular lens implantation

To report on amblyopia management of children with bilateral uneven cataracts treated by sequential intraocular lens implantation.

Children with bilateral uneven cataracts who needed bilateral cataract surgery were prospectively enrolled in Oxford Eye Center, Johannesburg, South Africa and Southwest Eye Hospital, Chong Qing, China. In the same patient, the amblyopic eye with the denser cataract underwent primary intraocular lens implantation, whereas the better eye was temporarily left aphakic as an alternative to patching. A secondary intraocular lens implantation was performed in the aphakic eye when best-corrected visual acuity in the amblyopic eye attained its best potential.

Thirteen children were included in this non-comparative study. Average age at surgery was 3.02+/-1.87 years with an average follow-up period of 9.35+/-5.23 years. In the amblyopic eyes, 10 out of 13 (77%) had less than 20/120 best-corrected visual acuity before amblyopia treatment. The optical penalization of the dominant eye (temporary aphakia) lasted on average 8.38+/-4.05 weeks. The best-corrected visual acuity of the amblyopic eye improved to 20/50 or better in six eyes (46%), and ranged from 20/60 to 20/200 in five eyes (38%); in remaining two eyes, the best-corrected visual acuity stayed below 20/200. Best-corrected visual acuity was restored to 20/30 or better following intraocular lens implantations in 12 of the dominant eyes (92%).

Optical penalization by temporary aphakia of the dominant eye is a convenient means for treating amblyopia in children with bilateral uneven cataracts.