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Cellular and molecular changes in mammary epithelial cells following irradiation
1Department of Radiation Therapy, University of Texas Medical Branch, Galveston 77550.
Radiation Research
|October 1, 1991
Abstract:
The present paper describes experiments conducted over the last several years which have focused primarily on the development of mammary tumors in BALB/c mice after neutron and gamma irradiation. Time-dose relationships for induction of mammary and lung tumors following irradiation with fission-spectrum neutrons and 137Cs gamma rays are described. Subsequent studies have used in vivo/in vitro approaches to characterize cellular and molecular changes. These studies suggest quantitative and qualitative differences in the effects of neutrons and gamma rays.