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Updated: Jun 25, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Women's health in menopause with a focus on hypertension
1Department of Cardiology, Isala Clinics, Zwolle, the Netherlands.
Insights
Menopause transition brings vasomotor symptoms and increased coronary heart disease (CHD) risk, particularly hypertension. Early risk factor identification is crucial for managing perimenopausal symptoms and considering safe hormone therapy in low-risk women.
Area of Science:
- Cardiology
- Endocrinology
- Women's Health
Background:
- Menopause transition is associated with vasomotor symptoms impacting daily life.
- Declining estrogen levels increase coronary heart disease (CHD) risk factors, notably hypertension.
- Hypertension onset during menopause can be misattributed to menopausal symptoms.
Purpose of the Study:
- To highlight the importance of risk factor identification in middle-aged women.
- To emphasize the need for proper evaluation and treatment of perimenopausal symptoms.
- To explore the potential for safe hormone prescription in early menopause.
Main Methods:
- Review of risk factors for coronary heart disease in women during menopause transition.
- Evaluation of the management of risk factors in middle-aged women.
- Analysis of the therapeutic window for hormone prescription in relation to menopause onset.
Main Results:
- Vasomotor symptoms are common during menopause and can affect daily activities.
- Hypertension risk becomes more apparent with estrogen decline.
- Risk factor management is often inadequate in middle-aged women.
Conclusions:
- Risk factor identification should be the primary step in evaluating and treating perimenopausal women.
- A window exists for safe hormone therapy in women at low CHD risk during early menopause.
- Addressing hypertension and other CHD risk factors is essential during the menopause transition.
Abstract:
In menopause transition many women have vasomotor symptoms which may affect their normal daily activities. With the decline in oestrogen levels, risk factors for coronary heart disease (CHD) become more apparent, especially hypertension. The onset of hypertension can cause a variety of complaints that are often attributed to the menopause. Risk factor identification is poorly managed in middle-aged women and should be the first step in the evaluation and treatment of women with perimenopausal symptoms. In women at low risk for CHD, there is still a window of opportunity for safe hormone prescription in the first years proximal to menopause. (Neth Heart J 2009;17:68-72.).
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