Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Techniques of Therapeutic Communication II: Focusing, Paraphrasing, and Summarizing01:23

Techniques of Therapeutic Communication II: Focusing, Paraphrasing, and Summarizing

Focusing involves centering a conversation on a message's critical elements or concepts. Focusing is valuable if the talk is vague or patients begin to repeat themselves. Sometimes, when patients are asked about their symptoms, they may go off-topic and try to tell their entire life story. Respectfully, the nurse should bring the conversation back into focus.
This therapeutic technique can also be used when a patient brings up pertinent information during a health-related conversation. The...
Elements Crucial for Effective Psychotherapy01:25

Elements Crucial for Effective Psychotherapy

Research has highlighted several critical factors that influence the effectiveness of psychotherapy, such as the therapeutic alliance, the therapist, and the client.
The Therapeutic Alliance
The therapeutic alliance refers to the relationship between the therapist and the client. The alliance strengthens when the therapist and the client engage in a nurturing, supportive, trusting, empathetic, and respectful relationship, improving therapeutic outcomes. Therapists must monitor this relationship...
Techniques of therapeutic communication I: Active Listening, Sharing Observations, Validation, and Using Touch01:15

Techniques of therapeutic communication I: Active Listening, Sharing Observations, Validation, and Using Touch

The history of therapeutic communication can be traced back to Florence Nightingale, who emphasized the importance of developing trusting relationships with patients. She taught that the presence of nurses with patients results in therapeutic healing.
Therapeutic communication is not the same as social interaction. Social interaction has no goal or purpose and consists of casual information sharing, whereas therapeutic communication has a plan or purpose for the conversation. Therapeutic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Institutional quality and patient safety programs: An overview for the healthcare epidemiologist.

Infection control and hospital epidemiology·2020
Same author

Impact of Empiric Treatment for Vancomycin-Resistant Enterococcus in Colonized Patients Early after Allogeneic Hematopoietic Stem Cell Transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2018
Same author

Where Are They Now? Assessing if Persons Returned to HIV Care Following Loss to Follow-Up by Public Health Case Workers Were Engaged in Care in Follow-Up Years.

AIDS patient care and STDs·2018
Same author

Clostridium difficile and the Consequences of Progress.

Journal of oncology practice·2017
Same author

Implementation and Operational Research: CD4 Count Monitoring Frequency and Risk of CD4 Count Dropping Below 200 Cells Per Cubic Millimeter Among Stable HIV-Infected Patients in New York City, 2007-2013.

Journal of acquired immune deficiency syndromes (1999)·2015
Same author

Provider Differences in Use of Implanted Ports in Older Adults With Cancer.

Medical care·2015
Same journal

Diagnostic performance of IgG against multiplex Aspergillus antigens (mx4) for identifying chronic pulmonary aspergillosis.

Medical mycology·2026
Same journal

The clinical utility of bronchoalveolar lavage galactomannan result stewardship within a tertiary medical system.

Medical mycology·2026
Same journal

Cross-reactivity of Cryptococcal Antigen Lateral Flow Assay with Basidiomycetous Yeasts.

Medical mycology·2026
Same journal

Cryptococcus gattii complex infections in southern Brazil: epidemiology, clinical features, management and outcomes from a 33-year cohort.

Medical mycology·2026
Same journal

HAC1 contributes to stress adaptation and virulence in the emerging fungal pathogen Candida auris.

Medical mycology·2026
Same journal

Multicenter Study Reveals Alarming Terbinafine Resistance in Trichophyton indotineae Isolates from Iran.

Medical mycology·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Recognizing therapeutic failure.

Kent A Sepkowitz1

  • 1Memorial Sloan-Kettering Cancer Center, New York 10065, USA. sepkowik@mskcc.org

Medical Mycology
|February 28, 2009
PubMed
Summary
This summary is machine-generated.

Recognizing invasive aspergillosis (IA) treatment failure is challenging due to conflicting data and the lack of sensitive markers. Clinicians must synthesize ambiguous radiologic, serologic, and clinical information for accurate patient assessment.

Related Experiment Videos

Last Updated: Jun 25, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
03:59

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Clinical Decision-Making

Background:

  • Invasive aspergillosis (IA) diagnosis is challenging.
  • Assessing treatment response in IA patients is complex.
  • Limited sensitive surrogate markers exist for monitoring IA treatment.

Observation:

  • Radiologic evidence (e.g., CT scans) often lags behind clinical improvement.
  • Clinical assessment is complicated by neutropenia status and degree of immunosuppression.
  • Antifungal treatment for IA requires a prolonged observation period compared to bacterial infections.

Findings:

  • Treatment failure assessment relies on synthesizing incomplete and conflicting data.
  • Multiple assessment modalities (radiologic, serologic, clinical) provide ambiguous information.
  • The lack of specific, sensitive markers complicates timely treatment failure identification.

Implications:

  • Accurate and timely assessment of IA treatment failure is critical for patient outcomes.
  • Clinicians need to carefully interpret diverse and often conflicting data points.
  • Improved diagnostic and monitoring tools are needed for invasive aspergillosis management.