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Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
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Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
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Clinical Applications of Epidermal Stem Cells01:19

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Classification of Epithelial Tissues: Simple Epithelium01:30

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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Updated: Jun 25, 2026

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
07:28

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

Epithelial resealing.

Beatriz Garcia-Fernandez1, Isabel Campos, Jennifer Geiger

  • 1Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.

The International Journal of Developmental Biology
|February 28, 2009
PubMed
Summary
This summary is machine-generated.

Simple epithelial tissues rapidly reseal wounds through a conserved "purse string" mechanism. This epithelial resealing process is vital for maintaining tissue integrity across various developmental stages and species.

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Last Updated: Jun 25, 2026

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Tissue Repair

Background:

  • Epithelial tissues form essential protective barriers.
  • Maintaining epithelial integrity is crucial despite damage from injury, inflammation, and cell turnover.
  • Wound healing varies significantly with developmental stage and tissue type.

Purpose of the Study:

  • To focus on the rapid resealing capacity of simple epithelial tissues.
  • To explore the "purse string" mechanism in embryonic wound repair.
  • To compare this mechanism with embryonic morphogenetic movements.

Main Methods:

  • Review of initial experiments demonstrating the purse string mechanism.
  • Comparison of epithelial resealing with embryonic morphogenetic movements.
  • Discussion of epithelial resealing in cell culture and adult tissues.

Main Results:

  • Epithelial tissues possess a rapid and efficient wound resealing capacity.
  • A purse string mechanism is identified for repairing embryonic wounds.
  • Conserved regulatory mechanisms for epithelial resealing exist across simple epithelia, developmental stages, and species.

Conclusions:

  • Epithelial resealing is a fundamental process for maintaining tissue integrity.
  • The purse string mechanism is a key component of rapid wound repair in epithelia.
  • Conserved mechanisms suggest broad applicability of epithelial resealing principles from embryos to adults.