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Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

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Updated: Jun 25, 2026

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
11:08

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy

Published on: March 13, 2014

Liver disease in pregnancy.

Noel M Lee1, Carla W Brady

  • 1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

World Journal of Gastroenterology
|February 28, 2009
PubMed
Summary

Pregnancy-specific liver diseases like HELLP syndrome and acute fatty liver require prompt management, often involving delivery. Chronic liver conditions seen during pregnancy necessitate optimized medical control for better outcomes.

Area of Science:

  • Hepatology
  • Obstetrics
  • Maternal-Fetal Medicine

Background:

  • Liver diseases in pregnancy are broadly classified into pregnancy-specific conditions and those occurring coincidentally.
  • Pregnancy-specific disorders include hyperemesis gravidarum, preeclampsia/eclampsia, HELLP syndrome, acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy.
  • Chronic liver diseases such as viral hepatitis, autoimmune hepatitis, and Wilson disease can also manifest during pregnancy.

Purpose of the Study:

  • To review the epidemiology, pathophysiology, diagnosis, and management of liver diseases encountered during pregnancy.
  • To highlight the distinct approaches required for pregnancy-specific versus chronic liver conditions.
  • To emphasize the collaborative care needed between obstetricians and hepatologists.

Main Methods:

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Last Updated: Jun 25, 2026

The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
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Published on: March 13, 2014

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  • Literature review and synthesis of existing knowledge on liver diseases in pregnancy.
  • Categorization of liver disorders based on their occurrence in pregnancy.
  • Discussion of diagnostic criteria and therapeutic strategies.

Main Results:

  • Pregnancy-specific liver disorders often necessitate fetal delivery and supportive care.
  • Management of chronic liver diseases during pregnancy focuses on disease control.
  • Cirrhosis in pregnancy presents unique and complex challenges.

Conclusions:

  • Effective management of liver disease in pregnancy relies on multidisciplinary collaboration.
  • Tailored treatment strategies are essential for both pregnancy-specific and chronic liver conditions.
  • Further understanding and research are needed for complex cases like cirrhosis in pregnancy.