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Updated: Jun 25, 2026

Highly-Multiplexed Tissue Imaging with Raman Dyes
Published on: April 21, 2022
[Raman spectra of murine skin irradiated by high power millimeter wave]
Jie Zhang1, Li-jun Han, Tao-rong Xie
1State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai. 99jiezi@163.com
Abstract:
An experimental study on Raman spectroscopy of normal murine skin and the skin irradiated by high power millimeter wave (HPMM) is presented. It is showed that the Raman spectra of normal skin mainly originate from collagen, and the characteristic peaks are 857, 936 and 1 658 cm(-1). The result showed that after irradiation by HPMM, the relative intensity of the characteristic peaks at 857 and 936 cm(-1) of Raman spectra was decreased. This meant that the collagen was destroyed and even daimaged. It was probably indicated that the skin tissue was damaged and could not be restored. The result also showed that the intensity of the characteristic peak at 1658 cm(-1) of the skin tissue irradiated by millimeter wave with the duration of 20 s decreased. It was considered that the protein in the skin was destroyed. Those results were consistent with macroscopic observation results.
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