Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung
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Published on: August 14, 2019
Chiaki Endo1, Masako Honda, Akira Sakurada
1Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. endo@idac.tohoku.ac.jp
Objective:
To examine whether immunocytochemistry can distinguish pulmonary large cell neuroendocrine carcinoma (LCNEC) among non-small cell lung cancers (NSCLCs).
Study Design:
Tumor touch imprint cytologic specimens of 109 lung cancers were studied. Immunocytochemistry was done using a total of 8 primary antibodies: chromogranin A, synaptophysin, neural cell adhesion molecule, neuron specific enolase, CK34betaE12, thyroid transcription factor-1, cytokeratin 18 and E-cadherin.
Results:
If 2 or 3 antibodies of chromogranin A, synaptophysin and neural cell adhesion molecule were stained positive and CK34betaE12 was not stained, pulmonary LCNEC can be selected accurately among other NSCLCs with 100% sensitivity and 100% specificity.
Conclusion:
This study reveals that immunocytochemistry can help distinguish LCNEC of the lung from other NSCLCs.