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Updated: Jun 25, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
Published on: March 7, 2022
[Plasmacytoid dendritic cells in pathophysiology of immune responses]
Paulina Kulig1, Karolina Wawro, Joanna Cichy
1Zakład Immunologii, Wydział Biochemii, Biofizyki i Biotechnologii Uniwersytetu Jagiellońskiego, Kraków.
Abstract:
Plasmacytoid dendritic cells (pDC), so named because of histological similarities to antibody-producing plasma cells, comprise a unique dendritic cell population. Despite their low numbers in blood they play a key role in anti-viral immunity, mainly through secreting massive amounts of type 1 interferon following an engagement of their Toll-like receptors, such as TLR7 and TLR9, by viral nucleic acids. In a mature state, pDC display a propensity to present antigens to naive lymphocytes. Through their unique potential to rapidly and efficiently secrete type I interferon and serve as antigen presenting cells, pDC are currently considered as one of the major regulators of immune responses.
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