Related Experiment Video
Updated: Jun 25, 2026

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Neuropathology of focal epilepsies: a critical review
1Department of Neuropathology, University Hospital Erlangen, Schwabachanlage 6, D-91054 Erlangen, Germany. bluemcke@uk-erlangen.de
Abstract:
A broad spectrum of structural lesions can be histopathologically identified in surgical brain specimens obtained from patients with focal, therapy-refractory epilepsies. In our experience with 4512 tissue samples collected at the German Neuropathological Reference Center for Epilepsy Surgery, three clinicopathological entities are most common: mesial temporal sclerosis (40%), long-term epilepsy-associated tumors (27%), and malformations of cortical development (13%). Notwithstanding, a systematic histopathological and molecular-genetic analysis is mandatory to unravel the underlying pathogenic mechanism of epilepsy-associated lesions and may contribute to our current understanding of pharmacoresistance and epileptogenesis. However, an interdisciplinary approach is necessary to further explore predictive parameters with respect to postsurgical seizure relief and memory impairment, and also to identify new pharmacological targets.
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures l: Introduction
Antiepileptic Drugs: Glutamate Antagonists
Seizures ll: Types

