Related Experiment Video

Updated: Jun 25, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

New therapeutic approaches for advanced gastrointestinal stromal tumors

Neeta Somaiah1, Margaret von Mehren

  • 1Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Hematology/Oncology Clinics of North America
|March 3, 2009
PubMed

Insights

Management of advanced gastrointestinal stromal tumors (GIST) is challenging due to imatinib resistance. This review covers surgical, local, and novel therapeutic strategies for imatinib-refractory GIST.

Area of Science:

  • Oncology
  • Gastrointestinal Surgery
  • Medical Therapeutics

Background:

  • Advanced gastrointestinal stromal tumors (GIST) present complex management challenges.
  • Imatinib resistance is a significant factor in GIST progression.
  • Most patients develop secondary genetic mutations leading to treatment failure.

Purpose of the Study:

  • To review current management strategies for advanced GIST.
  • To address the complexities of imatinib-refractory disease.
  • To highlight novel therapeutic approaches.

Main Methods:

  • Literature review of management strategies for advanced GIST.
  • Analysis of surgical interventions for GIST.
  • Evaluation of local treatment modalities for liver metastases.
  • Review of emerging therapeutic agents.

Main Results:

  • Primary imatinib resistance in GIST is rare.
  • Disease progression often results from acquired genetic alterations.
  • Multimodal treatment strategies are crucial for managing advanced GIST.

Conclusions:

  • Effective management of advanced GIST requires a comprehensive approach.
  • Surgical options and local therapies are vital for progressive disease.
  • Novel agents offer new hope for imatinib-refractory GIST patients.

More Related Videos

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib06:43

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib

Published on: April 3, 2026

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.