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Related Experiment Videos

Urinary cyclic AMP and post-traumatic acute renal failure.

V Vitek, P H Gold, W Gill

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |March 15, 1977
    PubMed
    Summary

    Urinary cyclic AMP (cAMP) levels fluctuate significantly in patients with severe illness or trauma, often increasing before acute renal failure (ARF) develops. Monitoring cAMP excretion can serve as an early indicator of ARF and recovery.

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    Area of Science:

    • Biochemistry
    • Nephrology
    • Critical Care Medicine

    Background:

    • Severe illness and trauma can lead to acute renal failure (ARF).
    • Early detection of ARF is crucial for timely intervention and improved patient outcomes.
    • Urinary cyclic AMP (cAMP) is a signaling molecule whose excretion patterns may reflect renal function.

    Purpose of the Study:

    • To investigate the daily urinary excretion of cyclic AMP (cAMP) in patients with severe trauma or illness.
    • To determine if urinary cAMP levels can serve as an early indicator of acute renal failure (ARF).
    • To assess the relationship between cAMP excretion and renal function parameters like creatinine clearance.

    Main Methods:

    • Consecutive daily urine samples were collected from 16 patients with severe trauma/illness and 20 healthy volunteers.

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  • Urinary cyclic AMP (cAMP) and creatinine levels were measured.
  • Creatinine clearance and urine volume were monitored.
  • Statistical analysis was performed to compare cAMP excretion between patient groups and controls and to correlate it with renal function.

    • Main Results:

    • Patients who developed ARF showed significantly altered urinary cAMP excretion compared to healthy controls.
    • In patients with normal renal function, cAMP excretion increased by 41% post-trauma, peaking at 24 hours.
    • In ARF patients, cAMP excretion was markedly reduced, declining proportionally with decreased creatinine clearance; the cAMP/creatinine ratio was less sensitive than 24-hour output.
    • Urinary cAMP and creatinine output correlated highly with diuresis in ARF patients and controls.

    Conclusions:

    • Urinary cyclic AMP (cAMP) excretion is a sensitive and early indicator of acute renal failure (ARF) onset in critically ill patients.
    • Monitoring daily urinary cAMP levels can aid in the early detection and assessment of ARF and its recovery.
    • Further research into urinary cAMP as a biomarker for renal function is warranted.