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Gramicidin-based Fluorescence Assay; for Determining Small Molecules Potential for Modifying Lipid Bilayer Properties
Published on: October 13, 2010
Interaction of genistein benzyl derivatives with lipid bilayers--fluorescence spectroscopic and calorimetric study
J Maniewska1, G Grynkiewicz, W Szeja
1Department of Biophysics, Wrocław Medical University, Wrocław, Poland.
Bioorganic & Medicinal Chemistry
|March 3, 2009
Abstract:
The purpose of the present paper was to assess the ability of genistein benzyl derivatives to interact with lipid bilayers. Calorimetric and fluorescence spectroscopic measurements revealed that, depending on the details of chemical structure, the studied compounds penetrated bilayers and affected their polar as well as hydrophobic regions. It was also found that physical state of bilayer played some role in flavonoid-lipid interactions.
