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Published on: August 15, 2022
Neurologic complications following lung transplantation
Sasa A Zivković1, Muhammad Jumaa, Nina Barisić
1VA Pittsburgh HCS, Pittsburgh, PA, USA. zivkovics@upmc.edu
Journal of the Neurological Sciences
|March 3, 2009
Summary
Neurologic complications are common in lung transplant recipients, often due to immunosuppressant toxicity or infections. These complications impact morbidity but not survival, though cystic fibrosis patients may face higher risks.
Area of Science:
- Medicine
- Neurosurgery
- Transplantation
Background:
- Neurologic complications are common after solid organ transplantation.
- The specific spectrum of these complications in lung transplant recipients remains poorly characterized.
Purpose of the Study:
- To characterize the spectrum of neurologic complications in adult lung allograft recipients.
- To identify potential causes and risk factors associated with these complications.
Main Methods:
- Retrospective analysis of medical records.
- 132 consecutive adult lung allograft recipients transplanted between 2001 and 2003.
- Follow-up data collected until December 31, 2005.
Main Results:
- 68% of lung transplant recipients experienced neurologic complications.
- Most frequent: impairment of consciousness (25%), neuromuscular issues (21%), headaches (20%).
- Common causes included immunosuppressant neurotoxicity (17%) and opportunistic infections (11%).
- No significant impact on posttransplant survival was observed.
- A trend suggested increased seizures and headaches in cystic fibrosis recipients.
Conclusions:
- Neurologic complications represent a significant source of morbidity in lung transplant recipients.
- High rates of immunosuppressant toxicity and opportunistic infections contribute to these complications.
- Cystic fibrosis patients may have an elevated risk, warranting further investigation.
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