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Updated: Jun 25, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Perinatal and neonatal risk factors for neurodevelopmental outcome in infants in Karaj
Farin Soleimani1, Roshanak Vameghi, Sahel Hemmati
1Pediatric Neurorehabilitation Research Center, Social Welfare and Rehabilitation Sciences University, Tehran, Iran.
Insights
This study identified key risk factors for developmental delay in Iranian infants, including seizures and preterm birth. Early detection and intervention are crucial for improving outcomes in high-risk newborns.
Area of Science:
- Pediatric Neurology
- Neonatal Development
- Public Health
Background:
- Developmental delay incidence is higher in high-risk infants.
- Risk factors for developmental delay in Iranian infants are not well-established.
- This study aimed to identify pre-, peri-, and neonatal risk factors in this population.
Purpose of the Study:
- Determine pre-, peri-, and neonatal risk factors for developmental delay in Iranian infants.
- Compare the incidence of these factors with the normal population.
- Provide insights for early intervention strategies.
Main Methods:
- Utilized the Infant Neurological International Battery (INIB) for developmental assessment.
- Conducted neurological examinations and completed questionnaires.
- Evaluated 6,150 infants over 12 months in Karaj, Iran, categorizing them into normal and abnormal developmental groups.
Main Results:
- Identified significant risk factors for developmental delay: postneonatal seizures (OR=5.54), neonatal seizures (OR=4.37), preterm delivery (OR=2.52), and type II pneumonia (OR=2.39).
- Mean participant age was 39 weeks.
- Established specific odds ratios and confidence intervals for identified risk factors.
Conclusions:
- Identified risk factors can guide early intervention and improve neonatal survival rates.
- Routine neurodevelopmental screening for all neonates and infants is recommended.
- Prioritize screening for high-risk infants if mass screening is not feasible due to economic limitations.
Background:
Although it is well-known that the incidence of developmental delay in high-risk infants is higher than in low-risk ones, little is known about the risk factors among Iranian infants. The objective of this study was to determine the various pre-, peri-, and neonatal factors in developmental delay in participants and to compare the incidence of each factor with that of the normal population.
Methods:
The Infant Neurological International Battery developmental assessment was employed as the diagnostic tool by a team of experts. Neurological examinations were performed and a questionnaire was completed as well. The subjects consisted of 6,150 infants divided into two groups respectively, with normal and abnormal scores for the evaluation over a period of 12 months in city of Karaj (Tehran Province).
Results:
The mean age of the participants was 39 weeks. Factors associated with a significant increased risk of developmental delay in the studied population included postneonatal seizures (OR=5.54, 95%CI: 3.1 - 9.6), neonatal seizures (OR=4.37, 95%CI: 1.7 - 10.8), preterm delivery (OR=2.52, 95%CI: 1.3 - 4.7), and type II pneumonia (OR=2.39, 95%CI: 1.4 - 3.8).
Conclusion:
To increase the survival rate of neonates and effectiveness of early intervention, the above-mentioned risk factors could be considered as valuable clues. Routine neurodevelopmental screening for neonates and infants for early detection of neurodevelopmental delays is highly recommended. If economic limitations prevent mass-screening of neonates, at least high-risk infants should be routinely re-evaluated.
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