Perinatal and neonatal risk factors for neurodevelopmental outcome in infants in Karaj

Farin Soleimani1, Roshanak Vameghi, Sahel Hemmati

  • 1Pediatric Neurorehabilitation Research Center, Social Welfare and Rehabilitation Sciences University, Tehran, Iran.

Insights

This study identified key risk factors for developmental delay in Iranian infants, including seizures and preterm birth. Early detection and intervention are crucial for improving outcomes in high-risk newborns.

Area of Science:

  • Pediatric Neurology
  • Neonatal Development
  • Public Health

Background:

  • Developmental delay incidence is higher in high-risk infants.
  • Risk factors for developmental delay in Iranian infants are not well-established.
  • This study aimed to identify pre-, peri-, and neonatal risk factors in this population.

Purpose of the Study:

  • Determine pre-, peri-, and neonatal risk factors for developmental delay in Iranian infants.
  • Compare the incidence of these factors with the normal population.
  • Provide insights for early intervention strategies.

Main Methods:

  • Utilized the Infant Neurological International Battery (INIB) for developmental assessment.
  • Conducted neurological examinations and completed questionnaires.
  • Evaluated 6,150 infants over 12 months in Karaj, Iran, categorizing them into normal and abnormal developmental groups.

Main Results:

  • Identified significant risk factors for developmental delay: postneonatal seizures (OR=5.54), neonatal seizures (OR=4.37), preterm delivery (OR=2.52), and type II pneumonia (OR=2.39).
  • Mean participant age was 39 weeks.
  • Established specific odds ratios and confidence intervals for identified risk factors.

Conclusions:

  • Identified risk factors can guide early intervention and improve neonatal survival rates.
  • Routine neurodevelopmental screening for all neonates and infants is recommended.
  • Prioritize screening for high-risk infants if mass screening is not feasible due to economic limitations.
Abstract

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