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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Prevention of meningococcal serogroup C disease by NeisVac-C

Ray Borrow1, Jamie Findlow

  • 1Vaccine Evaluation Unit, Health Protection Agency North West, PO Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Manchester, M13 9WZ, UK. ray.borrow@hpa.org.uk

Expert Review of Vaccines
|March 3, 2009
PubMed

Insights

NeisVac-C is a safe and effective meningococcal serogroup C conjugate vaccine for all ages. It provides protection and can boost responses to other crucial vaccines like Haemophilus influenzae type b (Hib).

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • NeisVac-C is a licensed meningococcal serogroup C conjugate vaccine.
  • A single infant dose may suffice until a second-year booster, with antibody persistence being key for long-term protection.
  • Meningococcal serogroup C disease is a significant public health concern.

Purpose of the Study:

  • To evaluate the safety, immunogenicity, and efficacy of NeisVac-C across various age groups.
  • To assess the potential of NeisVac-C to enhance immune responses when coadministered with other vaccines.
  • To understand the correlates of protection for NeisVac-C against meningococcal serogroup C disease.

Main Methods:

  • Clinical trials involving infants, toddlers, children, and adults.
  • Administration of NeisVac-C as a single or booster dose.
  • Co-administration studies with Haemophilus influenzae type b (Hib) and tetanus toxoid conjugate vaccines.
  • Measurement of serum bactericidal antibody and immune memory responses.

Main Results:

  • NeisVac-C demonstrated safety, immunogenicity, and efficacy in all tested age groups.
  • A single infant dose provided protection until a booster dose.
  • NeisVac-C enhanced immune responses to coadministered Hib-tetanus toxoid conjugate vaccines and tetanus toxoid.
  • Antibody persistence, not immune memory, was identified as the correlate for long-term protection.

Conclusions:

  • NeisVac-C is a well-tolerated and effective vaccine for preventing meningococcal serogroup C disease.
  • The vaccine can be safely coadministered with other routine childhood vaccines, potentially improving overall vaccine efficacy.
  • NeisVac-C contributes to public health by providing robust protection against a serious bacterial infection.

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