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Related Experiment Video

Updated: Jun 25, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: 8-year

Florian Rossner1, Mathias Rossner, Vanessa Hartmann

  • 1Division of Evidence Based Medicine, Klinik für Dermatologie, Charité Universitätsmedizin Berlin, Berlin, Germany.

Journal of Cosmetic Dermatology
|March 3, 2009
PubMed
Summary

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Polylactic acid (PLA) fillers can cause nodules, a common adverse reaction. Increased dilution of PLA may reduce these risks, but nodule formation remains a characteristic concern.

Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Cosmetic Procedures

Background:

  • Polylactic acid (PLA) is a semipermanent injectable filler used in aesthetic medicine.
  • PLA requires dilution with sterile water prior to injection.
  • PLA use has been linked to an increased incidence of adverse reactions, particularly subcutaneous nodule formation.

Purpose of the Study:

  • To investigate adverse reactions associated with Polylactic acid (PLA) fillers.
  • To identify potential risk factors for PLA-induced adverse events.
  • To analyze data from a partially population-based registry spanning 8 years.

Main Methods:

  • Data collected via a partially population-based registry in Berlin, supplemented by private practices.
  • Dermatologists, plastic surgeons, and other specialists reported adverse events.

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Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

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Last Updated: Jun 25, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
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Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration

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  • Patients underwent assessment using a standardized questionnaire; analysis primarily descriptive.

    • Main Results:

    • Twenty-two patients experienced adverse reactions to PLA, with nodule formation reported in all cases.
    • Severe nodule formation occurred in 59.1% of patients, appearing after a mean latency of 6 months.
    • Adverse event frequency decreased following updated recommendations on product dilution.

    Conclusions:

    • Polylactic acid (PLA) can induce subcutaneous nodules in patients undergoing aesthetic treatments.
    • Increased dilution of PLA correlates with a reduced risk of adverse reactions.
    • Nodule formation persists as a notable characteristic of PLA fillers despite dilution adjustments.