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Translating transplantation tolerance in the clinic: where are we, where do we go?

M Goldman1, K Wood

  • 1Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium. mgoldman@ulb.ac.be

Clinical and Experimental Immunology
|March 3, 2009
PubMed

Insights

Clinical trials are exploring safe immunosuppression withdrawal for organ transplant recipients. While challenges remain, biomarker-guided minimization may soon be standard practice for immune tolerance.

Area of Science:

  • Transplantation immunology
  • Clinical translation

Background:

  • Research networks focus on immune tolerance in clinical settings.
  • Pilot trials investigate immunosuppression withdrawal in kidney and liver transplant recipients.

Purpose of the Study:

  • To assess the feasibility of drug withdrawal in organ transplant recipients.
  • To explore the potential of immunosuppression minimization strategies.

Main Methods:

  • Support of pilot trials for immunosuppression withdrawal.
  • Focus on clinical translation of immune tolerance research.

Main Results:

  • Significant hurdles exist for routine drug weaning in transplant recipients.
  • Recent advances indicate potential for future immunosuppression minimization.

Conclusions:

  • Safe and routine immunosuppression withdrawal remains a challenge.
  • Validated biomarkers may enable future immunosuppression minimization in organ transplantation.

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