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Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial
H C Diener1, A Gendolla, A Feuersenger
1Department of Neurology and Headache Centre, University Hospital Essen, Essen, Germany. h.diener@uni-essen.de
Cephalalgia : an International Journal of Headache
|March 3, 2009
Summary
Telmisartan 80 mg may be effective for migraine prophylaxis. Post hoc analysis showed a significant reduction in migraine days for patients taking telmisartan compared to placebo.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a common neurological disorder.
- Current prophylactic treatments have limitations.
Purpose of the Study:
- To evaluate the efficacy of telmisartan 80 mg for migraine prophylaxis.
- To assess the reduction in migraine days and responder rates.
Main Methods:
- Randomized, double-blind, placebo-controlled trial.
- 95 migraine patients with 3-7 attacks/month.
- 12-week treatment period with telmisartan 80 mg or placebo.
Main Results:
- Initial analysis showed no significant difference in migraine day reduction (1.65 vs 1.14).
- Post hoc analysis revealed a 38% reduction in migraine days with telmisartan vs 15% with placebo (P=0.03).
- Responder rates were borderline significant (40% vs 25%, P=0.07); adverse events were similar.
Conclusions:
- Telmisartan 80 mg may offer a potential new treatment option for migraine prophylaxis.
- Further research is warranted to confirm efficacy and optimal dosing.
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