Related Experiment Video
Updated: Jun 25, 2026
08:46
A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
Published on: March 7, 2017
Multiple pilomatricomas and gliomatosis cerebri--a new association?
Tina Wachter-Giner1, Imke Bieber, Monika Warmuth-Metz
1Department of Dermatology, University of Wuerzburg, Germany. giner_t@klinik.uni-wuerzburg.de
Pediatric Dermatology
|March 3, 2009
Summary
Multiple pilomatricomas, a rare skin tumor, developed in a teen with gliomatosis cerebri. This case presents a potential new association between the brain tumor and multiple pilomatricomas, requiring further investigation.
Area of Science:
- Dermatology
- Oncology
- Neurology
Background:
- Pilomatricomas are benign skin tumors arising from hair follicle matrix cells.
- Multiple pilomatricomas occur in 2-3.5% of cases and can be linked to genetic syndromes.
- Gliomatosis cerebri is a rare primary brain tumor characterized by diffuse infiltration.
Observation:
- A 15-year-old male patient with gliomatosis cerebri and epilepsy was treated with temozolomide and oxcarbazepine.
- Over one year, the patient developed four distinct cutaneous nodules on his face and arm.
- Excision and histological examination confirmed the nodules as pilomatricomas.
Findings:
- This report details the first instance of a patient with gliomatosis cerebri developing multiple pilomatricomas.
- The pilomatricomas were excised under local anesthesia and histologically confirmed.
- The patient's treatment regimen included temozolomide and oxcarbazepine for gliomatosis cerebri.
Implications:
- This case highlights a potential, previously undocumented association between gliomatosis cerebri and multiple pilomatricomas.
- Further research is needed to determine if this association is coincidental or represents a new clinical link.
- Understanding this potential connection may inform future diagnostic and treatment strategies for patients with rare neurological and dermatological conditions.
