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Updated: Jun 25, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

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Reflux and sleeping disorders: a systematic review.

P D Karkos¹, S C Leong, J Benton

¹Department of Otolaryngology, Liverpool University Hospitals, UK. pkarkos@aol.com

The Journal of Laryngology and Otology

|March 3, 2009

Summary

This summary is machine-generated.

Limited evidence supports a link between night-time reflux and snoring or sleep apnea. Current research relies on low-quality studies, necessitating further investigation into this laryngology topic.

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Area of Science:

Otolaryngology
Sleep Medicine
Gastroenterology

Background:

Laryngopharyngeal reflux (LPR) is a significant area of research in laryngology.
Supraesophageal symptoms like asthma and laryngospasm are potentially linked to supine reflux.
This review focuses on the association between night-time reflux, snoring, and sleep apnea.

Purpose of the Study:

To evaluate the evidence quality for a correlation between night-time reflux and snoring/sleep apnea.
To synthesize current research on the relationship between LPR and sleep-disordered breathing.

Main Methods:

A comprehensive Medline search was conducted using relevant keywords.
Literature review focused on randomized and non-randomized controlled trials.
Inclusion of studies across pediatric and adult populations, excluding non-English papers.

Main Results:

No randomized controlled trials or meta-analyses were found directly addressing reflux, snoring, and apnea.
The existing literature describes a potential correlation but lacks robust evidence.

Conclusions:

The role of night-time reflux in pediatric and adult snoring and apnea is suggested.
Current evidence is primarily derived from uncontrolled studies and case reports, indicating a low level of evidence.
Further high-quality research is needed to establish a definitive link.