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Hyperreactivity and bronchial obstruction.

S Bianco1, M Robuschi, P Sestini

  • 1Institute of Respiratory Diseases of Milano, Italy.

Respiration; International Review of Thoracic Diseases
|January 1, 1991
PubMed
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Bronchospasm significantly impacts chronic obstructive pulmonary disease (COPD), necessitating treatment with bronchodilators even for seemingly irreversible obstruction. COPD patients show reactivity to various stimuli, supporting regular bronchodilator therapy.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Obstructive lung diseases like asthma and COPD share common features.
  • Bronchospasm is a key component in both conditions, often underestimated in COPD.

Purpose of the Study:

  • To discuss the obstructive components in bronchial asthma and COPD.
  • To highlight the role of bronchospasm in COPD and its treatment implications.
  • To investigate COPD patient responses to various stimuli.

Main Methods:

  • Review of obstructive components in bronchial asthma and COPD.
  • Analysis of bronchospasm's role and treatment in COPD.
  • Evaluation of COPD patient responses to chemical and osmotic stimuli.

Main Results:

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  • Bronchospasm is significant in COPD and warrants treatment with beta 2-stimulants, antimuscarinics, or theophylline.
  • COPD patients exhibit positive responses to chemical and osmotic stimuli, albeit less than asthmatics.
  • Geometric factors may contribute to anomalous responses in COPD patients.

Conclusions:

  • Regular bronchodilator treatment is indicated for COPD due to the antireactive properties of these medications.
  • The long-term prognostic benefit of bronchodilator therapy in COPD requires further investigation.