IRS-2 and its involvement in diabetes and aging
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Updated: Jun 25, 2026

Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay
Published on: July 15, 2025
1Rigel Pharmaceuticals, Inc., South San Francisco, California 94080, USA.
Abstract:
Insulin receptor substrate 2 (IRS-2) is a key molecule in insulin signaling pathway, serving as an adaptor protein to insulin receptor to activate downstream kinase cascades, including MAP kinase and PI-3 kinase cascades. While reduced IRS-2 expression is tightly associated with diabetes and insulin resistance in various rodent diabetic models, this gene is also suggested to play a critical role in reproductive system and pancreas development. Recently, IRS-2 is demonstrated to be actively involved in lifespan regulation. In this chapter, we attempt to give a brief review of what we have learned about this molecule in metabolism and growth.
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