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Updated: Jun 25, 2026
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Published on: June 20, 2025
Skin necrosis after self-administered intramuscular diclofenac
1Department of Orthopedics A, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel-Aviv 64239, Israel. ofiruri@gmail.com
Summary
Intramuscular diclofenac injections can rarely cause tissue necrosis. This case suggests a vascular cause, specifically accidental arterial injection, leading to necrosis.
Area of Science:
- Pharmacology
- Vascular Medicine
- Pathology
Background:
- Intramuscular diclofenac is a common analgesic.
- Tissue necrosis is a rare but severe complication of intramuscular injections.
- The exact mechanism of diclofenac-induced tissue necrosis remains unclear.
Observation:
- A case of tissue necrosis following diclofenac self-administration is presented.
- The injection was inadvertently administered into an arterial perforator branch of the superficial femoral artery.
- This highlights a potential risk associated with self-administered intramuscular injections.
Findings:
- The reported case supports a vascular pathogenesis for tissue necrosis after intramuscular diclofenac.
- Accidental arterial injection may lead to localized tissue damage and necrosis.
- This emphasizes the importance of correct injection technique.
Implications:
- Understanding the vascular mechanism is crucial for preventing diclofenac-induced tissue necrosis.
- Physicians should educate patients on safe self-administration techniques.
- Further research into the vascular effects of intramuscular diclofenac is warranted.
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