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Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: Jun 25, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Autoimmune thyroid disorders in patients with psoriasis.

Ulker Gul1, Müzeyyen Gonul, Ilhan Kaya

  • 1Ankara Numune Education and Research Hospital, 2nd. Dermatology Clinic, Ankara, Turkey.

European Journal of Dermatology : EJD
|March 3, 2009
PubMed
Summary

This study found no difference in thyroid autoimmunity markers between patients with psoriasis and a healthy control group. However, elevated free thyroxine (FT4) levels were observed in psoriasis patients, and longer disease duration correlated with thyroiditis and nodules.

Related Experiment Videos

Last Updated: Jun 25, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Area of Science:

  • Endocrinology
  • Dermatology
  • Immunology

Background:

  • Psoriatic arthritis is linked to thyroid autoimmunity, but this association is unstudied in psoriasis without arthritis.
  • Investigating thyroid autoimmunity in psoriasis patients is crucial for understanding potential systemic implications.

Purpose of the Study:

  • To assess the prevalence of autoimmune thyroid disorders in patients with psoriasis who do not have psoriatic arthritis.
  • To compare thyroid function and antibody levels between psoriasis patients and a healthy control group.

Main Methods:

  • A cohort of 105 psoriasis patients (without arthritis) and 96 controls (tinea pedis) were evaluated.
  • Thyroid function tests (TSH, FT3, FT4) and autoantibodies (AbTG, AbTPO) were measured.
  • Thyroid ultrasonography was performed, and Psoriasis Area and Severity Index (PASI) scores were recorded.

Main Results:

  • Significantly increased free thyroxine (FT4) levels were noted in the psoriasis group compared to controls.
  • No statistically significant differences in antithyroglobulin (AbTG) or antithyroidperoxidase antibody (AbTPO) levels were found.
  • Patients with thyroiditis and nodules on ultrasonography had longer disease durations.

Conclusions:

  • Autoimmune thyroid disorders do not appear to be more prevalent in patients with psoriasis (without arthritis) compared to healthy individuals.
  • Elevated FT4 warrants further investigation, while autoantibody levels suggest no increased risk of thyroid autoimmunity.
  • Longer psoriasis disease duration may be associated with specific thyroid ultrasonographic findings.