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Updated: Jun 25, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
Published on: April 30, 2020
An evaluation of the completeness of reporting of childhood tuberculosis
Insights
The Enhanced Tuberculosis Surveillance (ETS) scheme significantly under-reports childhood tuberculosis cases, particularly in children under five. Improved reporting is crucial for accurate public health planning and resource allocation.
Area of Science:
- Public Health
- Epidemiology
- Pediatrics
Background:
- The sensitivity of the Enhanced Tuberculosis Surveillance (ETS) scheme for monitoring pediatric tuberculosis in the UK is not well-established.
- Accurate surveillance data is essential for effective public health interventions and resource allocation for tuberculosis control.
Purpose of the Study:
- To evaluate the sensitivity of the Enhanced Tuberculosis Surveillance (ETS) scheme in capturing pediatric tuberculosis cases in the UK.
- To identify demographic factors influencing reporting rates within the ETS scheme.
Main Methods:
- A prospective observational study was conducted using the British Paediatric Surveillance Unit (BPSU) reporting scheme.
- Paediatric tuberculosis cases reported to the BPSU between January and December 2004 were matched with records from the ETS database.
- Sensitivity was assessed by comparing case ascertainment between the two surveillance systems.
Main Results:
- Out of 320 cases reported to the BPSU, an estimated 557 pediatric tuberculosis cases occurred in England, Wales, and Northern Ireland in 2004.
- 40% of cases were reported to both BPSU and ETS, 18% to BPSU only, and 42% to ETS only.
- Children under 5 years were significantly less likely to be reported to ETS compared to older children (p<0.01).
Conclusions:
- There is substantial under-reporting of childhood tuberculosis, with the ETS missing approximately 20% of cases.
- The ETS scheme may miss a disproportionately higher number of tuberculosis cases in children under 5 years.
- Enhanced efforts are required to improve the completeness of the ETS for pediatric tuberculosis surveillance and inform resource allocation.
Abstract:
The sensitivity of the Enhanced Tuberculosis Surveillance (ETS) scheme for monitoring tuberculosis in children is unknown. We used the British Paediatric Surveillance Unit (BPSU) reporting scheme to conduct a prospective observational study of tuberculosis in children aged <16 yrs in the UK. Reported cases were then matched with records from the ETS database. A total of 320 cases were reported to the BPSU between January and December 2004. We estimated that there were 557 paediatric cases in England, Wales and Northern Ireland in 2004: 222 (40%) cases reported to both BPSU and ETS, 98 (18%) reported to BPSU but not ETS and 237 (42%) reported to ETS but not BPSU. Children aged <5 yrs were significantly less likely to be reported to ETS compared with older children (p<0.01). There is substantial under-reporting of childhood tuberculosis, especially of children aged <5 yrs. ETS provides a representative picture of the demographics but may miss approximately 20% of cases. This should be taken into account when planning training and resource requirements for tuberculosis. Increased efforts are needed to ensure that all paediatric cases are reported to ETS.
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