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Interindividual divergence in the relationship between the values of plasma glucose and hemoglobin A1c in type 2
Michiyo Fukudome1, Mitsuhiro Nakazaki, Eriko Fukushige
1Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University.
Objective:
To verify the relationships between the values of plasma glucose (PG) and hemoglobin A(1c)(HbA(1c)) in type 2 diabetic outpatients.
Methods:
The pre- and postbreakfast PG and HbA(1c) values were monitored every month for 44-90 months. The single regression lines between the values of PG and HbA(1c) were compared for the slopes and intercepts on the designated ordinates of the regression lines.
Patients Or Materials:
Nine patients of type 2 diabetes not treated with insulin: three males and six females, aged 43-79 years participated.
Results:
The HbA(1c) level was combined with the pre- and postbreakfast PG values obtained at one month prior to its determination, because the combinations were correlated most strongly. The slopes of the regression line ranged from 0.33-0.50%/mmol/L and the intercepts at PG level equal to 9.6 mmol/L ranged from 6.95-9.77% in the relationship between the values of 1-month earlier prebreakfast PG and HbA(1c). Twenty-eight pairs had significantly different intercepts. Meanwhile, there was no pair that had significantly different slopes. Similar results were obtained in the relationship between the values of 1-month earlier postbreakfast PG and HbA(1c).
Conclusion:
There was interindividual divergence of the regression lines which was due to the difference in the intercepts but not the slopes.
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