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Juvenile polyposis complicated with protein losing gastropathy
Kentaro Yamashita1, Mayuko Saito, Miki Itoh
1The First Department of Internal Medicine, Sapporo Medical University. ykentaro@sapmed.ac.jp
Internal Medicine (Tokyo, Japan)
|March 3, 2009
Summary
Juvenile polyposis can cause severe anemia and hypoproteinemia due to protein-losing gastropathy. Total gastrectomy successfully treated a patient with severe gastric polyposis and related complications.
Area of Science:
- Gastroenterology
- Medical Genetics
Background:
- Juvenile polyposis is a rare inherited gastrointestinal disorder.
- Characterized by numerous hamartomatous polyps in the gastrointestinal tract.
- Associated with an increased risk of gastrointestinal bleeding and malignancy.
Observation:
- A 28-year-old male presented with chronic bloody stool and was diagnosed with juvenile polyposis.
- The patient had extensive colonic polyps and numerous gastric polyps.
- Progressive polyposis led to intractable anemia and severe hypoproteinemia.
Findings:
- Albumin scintigraphy confirmed protein-losing gastropathy secondary to gastric polyposis.
- The patient underwent total gastrectomy at age 34.
- Surgical intervention resulted in significant and sustained clinical improvement.
Implications:
- Total gastrectomy can be an effective treatment for severe, refractory juvenile polyposis with protein-losing gastropathy.
- Highlights the importance of considering gastrectomy in managing advanced cases.
- Suggests a potential curative approach for debilitating symptoms of juvenile polyposis.
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