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Updated: Jun 25, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
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[An additional role of FTY720 in chronic colitis].

Toshimitsu Fujii1, Mamoru Watanabe

  • 1Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|March 3, 2009
PubMed
Summary

FTY720 prevents inflammatory bowel disease by altering CD4+ T cell migration. This sphingosine-1-phosphate receptor modulator directs T cells to bone marrow, preventing their movement to disease sites.

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Area of Science:

  • Immunology
  • Pharmacology

Context:

  • Inflammatory bowel diseases (IBD) involve colitogenic memory CD4+ T cells migrating to inflamed tissues.
  • The mechanism of FTY720 (sphingosine-1-phosphate receptor modulator) in controlling T cell migration, especially without lymph nodes, is not fully understood.

Purpose:

  • To investigate FTY720's effect on T cell trafficking and its potential to prevent T cell-mediated diseases.
  • To determine if FTY720 can control T cell migration independently of lymphoid tissues.

Summary:

  • FTY720 prevented colitis development in SCID mice transferred with colitogenic CD4+ T cells.
  • FTY720 suppressed CD4+ T cell recirculation in mice lacking lymph nodes and spleens, decreasing peripheral blood counts and increasing bone marrow counts.
  • FTY720 also prevented colitis in lymphopenic, lymph node- and spleen-deficient mice.

Impact:

  • FTY720 may have a direct role in trafficking CD4+ T cells to the bone marrow.
  • This mechanism could prevent diseases mediated by memory T cells, such as inflammatory bowel diseases.