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Transdermal delivery of ketorolac
Chandra Amrish1, Sharma Pramod Kumar
1Institute of Pharmacy, Bundelkhand University, Jhansi, India. amrish_chandra@yahoo.com
Summary
This study explored transdermal delivery of ketorolac using reservoir patches. Eucalyptus oil significantly enhanced drug permeation, showing promise for effective transdermal ketorolac delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Dermatology
Background:
- Transdermal drug delivery offers a non-invasive route for systemic medication.
- Ketorolac, a potent analgesic, faces challenges in transdermal delivery due to low skin permeability.
- Reservoir-type transdermal patches are investigated to overcome these delivery barriers.
Purpose of the Study:
- To investigate the efficacy of permeation enhancers for ketorolac transdermal delivery.
- To fabricate and evaluate a reservoir-type transdermal patch for ketorolac.
- To assess the impact of different enhancers and skin abrasion on drug permeation.
Main Methods:
- Fabrication of a reservoir-type transdermal patch with a hydroxypropyl methyl cellulose (HPMC) gel core.
- Incorporation of various permeation enhancers (e.g., eucalyptus oil, Transcutol) into the gel system.
- In vitro permeation studies across rat skin, including evaluation of abrading gel treatment.
Main Results:
- Eucalyptus oil demonstrated the highest permeation enhancement for ketorolac, followed by Transcutol, DMSO, and d-limonene.
- Maximum flux of 66.38 microg/cm(2)/h was achieved with 10% eucalyptus oil.
- Skin abrasion with crushed apricot seed gel resulted in a 5.16-fold enhancement, achieving a flux of 93.10 microg/cm(2)/h.
Conclusions:
- Reservoir-type transdermal patches are feasible for ketorolac delivery.
- Eucalyptus oil is a highly effective chemical permeation enhancer for transdermal ketorolac.
- Combination strategies, including enhancers and physical methods like abrasion, can significantly improve transdermal permeation.
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