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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

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Related Experiment Video

Updated: Jun 25, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

[Menopause, obesity, and bone status].

Zofia Ostrowska¹

¹Zakład Biochemii Klinicznej w Zabrzu Slaskiego Uniwersytetu Medycznego w Katowicach, Poland.

Postepy Higieny I Medycyny Doswiadczalnej (Online)

|March 3, 2009

Summary

Obesity may not increase osteoporosis risk; increased adipose tissue may protect bones. Hormones and cytokines influence bone density via the RANKL/RANK/OPG system.

Area of Science:

Endocrinology
Bone Biology
Metabolic Disorders

Context:

Emerging research challenges the traditional view of obesity as a risk factor for osteoporosis.
Increased adipose tissue mass is increasingly recognized for potential protective effects on bone health.

Purpose:

To explore the mechanisms by which adipose tissue may influence bone metabolism and density.
To investigate the role of various hormones and cytokines in mediating the bone-protective effects of adipose tissue.

Summary:

Recent studies suggest obesity does not elevate osteoporosis risk, with increased adipose tissue potentially offering protection.
This protective effect may stem from increased mechanical loading on bone, promoting anabolism.
Hormonal changes in postmenopausal women, including estrogens, androgens, and leptin, alongside the RANKL/RANK/OPG system, are implicated in bone regulation.

Related Experiment Videos

Last Updated: Jun 25, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Impact:

Findings suggest a re-evaluation of the relationship between body composition and bone health.
Identifies key hormonal and cellular pathways (RANKL/RANK/OPG) involved in adipose tissue's influence on bone metabolism.
Potential implications for novel therapeutic strategies targeting osteoporosis and metabolic bone diseases.