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Updated: Jun 25, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Atypical thyrotropin-secreting pituitary microadenoma revealed by severe osteoporosis in a young man
Alexis de Rougemont1, Marie-Gabrielle Mourot, Jean-Paul Riou
1Service d'Endocrinologie-Diabétologie, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, 69003, France. alexis.de.rougemont@sante.univ-lyon1.fr
Abstract:
For 10 years, a young man was followed for a severe osteoporosis associated with a considerable reduction in height and a massive weight loss. The constant increase of signs of tissue impregnation with thyroid hormones and the molar ratios of alpha-TSH suggested an inappropriate secretion of thyrotropin. Magnetic resonance imaging finally revealed a thyrotropic microadenoma of the pituitary gland. This case gives some new additional information on thyrotropin-induced osteoporosis. To our knowledge such a case has never been reported in the literature.
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